The Presbyterian Church has maintained a strong sense of social concern for the people in Taiwan and for the future of the nation. It has sought to uphold human rights and to stress the meaning and value of human life in the midst of rapid social change. In the 1970s the Presbyterian Church in Taiwan issued three significant public statements, which led to the arrest and imprisonment of church leaders including the then general secretary of the church. The church has made significant contributions to Taiwanese society and through preaching, healing, and other forms of ministry it continues to work towards indigenization of the faith. Among its major programmes and activities are: lay training and theological programmes, senior citizens’ university, Christian literature programmes, spiritual formation and discipleship seminars, medical ministries, women’s ministry, youth ministry, campus ministry among students, crisis and family counselling, and community development especially among indigenous people. It also expresses its social concern through its various social service agencies and in its response to natural disasters both in Taiwan and overseas. The Presbyterian Church in Taiwan has three theological seminaries, one Bible college, two universities, three high schools, three hospitals, and a nursing school.

The Presbyterian Church in Taiwan maintains fraternal church relationships with over thirty churches in Africa, Asia, Europe, Latin and North America, and Pacific.